Morphological, Histological Changes and Acetyl Cholinesterase Activity in Chicken Embryos After Exposure to Abamectin Insecticide

Abamectin is a bio-insecticide, derived from the soil bacteria Streptomyces avermitilis. This insecticide used in public health and agriculture to protect crops. Major adverse impacts of are neurological symptoms acting on peripheral nervous system. The aim current study reveal toxic effects chick embryo Ross 308 including morphological histological changes acetyl cholinesterase activity. 120 fresh fertilized eggs were divided into 6 groups; two them as control. After 2 days incubation, injected with 100 µL solution (diluted at concentrations 360, 540, 900 1800 ppm) yolk sac. Results showed that mortality increased significantly chicks treated Abamectin, but had lower weight comparison control groups. Treated started hatching day 22 physically weak drooping limbs, paralysis then died after 24 hours hatching. Some did not normally hatch needed assistance. They characterized by limb defects, failure retraction sac bleeding. Histological examination liver hepatic cell degeneration, congestion central vein, infiltration inflammatory cells hepatocytes necrosis. Furthermore, Acetyl enzyme analysis significant decrease activity which leads inhibition body systems. It concluded low high concentration has changing some morphological, characteristics